Amino acid sequence studies with Bence-Jones proteins.
نویسندگان
چکیده
منابع مشابه
Metabolism of Bence Jones Proteins.
Bence Jones proteins are molecules of about 40,000 mol wt present in the urine of many patients with plasma cell malignancy. These microglobulins, which are synthesized in plasma-cell tumors (1, 2), share many immunochemical and physicochemical features with the larger 6.6 S y-globulins. That Bence Jones proteins are similar to or identical with components of the larger y-globulins has been sug...
متن کاملHuman Antibody Reacting with Bence Jones Proteins
The light (L) polypeptide chains of the human T-globulins carry antigenic determinants designated as group 1 or 2 (1-3). Allotypic determinants designated InV have been found in association with the L chains of 3,,-globulin (4). Natural ly occurring human ant ibody directed toward L chain determinants has been described in detail only for the InV antigens (5). The present studies utilize human ...
متن کاملStudies of Bence Jones Proteins by Immunonephelometry*t
Plasma cell dyscrasia is a disease caused by a monoclonal population of plasma cells. Most often the workup for this disease is prom pted by the appearance of a paraprotein in serum, but a significant num ber of cases exhibit only a Bence Jones protein. Immunofixation electrophoresis is the most sensitive m ethod presently used for identifying Bence Jones protein uria. This methodology is labo...
متن کاملAmino acid sequence of an amyloidogenic Bence Jones protein in myeloma-associated systemic amyloidosis.
The complete amino acid sequence of an amyloidogenic Bence Jones protein (NIG-84) from an individual with myeloma-associated systemic amyloidosis has been determined. The protein, with a blocked N-terminus, represents a complete light chain consisting of 217 residues and it has a structural feature characteristic of the V lambda II subgroup. In addition to a two-residue insertion at positions 2...
متن کاملThe Amino Acid Sequence of a K Type Bence-Jones Protein
The amino acid sequence of the human K Bence-Jones protein Ag containing 214 residues has been determined by a combination of four procedures: sequence analysis of the tryptic and of the chymotryptic peptides of the carboxymethylated protein described earlier and partial sequence analysis of the tryptic peptides of the aminoethylated protein and of the peptic peptides of the oxidized protein de...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1965
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.53.6.1403